AP - When the Memphis Grizzlies lost Zach Randolph to a torn ligament on Jan. 1, the question then was whether they could remain a playoff-caliber team in his absence.
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Self help is the perfect help it is stated, self-assist or self-improvement is something, which has attracted the attention of people since ages. Self assistance is the best selection for individual for a revived personality, self assist is de facto is the most effective remedy for one?s problem as a result of identifying one?s problem is crucial for any form of enchancment program to launched in one?s lifestyle. There is a huge spectrum of self improvement that individual a on the lookout in the present very demanding atmosphere we human beings are exposed. Schooling, economic, intellectual, emotional, and lots of different fronts are just a few?xheli coupon to name where folks seek the help of both books or consultants for grooming.
There are lots of product in addition to, services out there in the market focusing on the audience looking for self enchancment; these employ their own focus, strategies, beliefs, and techniques. The target is predominantly to assign customised companies for their clients. Folks usually go for self help or self reconstruction books over more elaborate classes resulting from lack of time. Books are an incredible firm for readers, and there are cases that nice books have pressured non-readers to migrate to sound readers. Contents of a self help books is commonly phrases of knowledge which are organized chronologically, the potential of taking a look at issues in a more positive format is often the essence.
Self help has developed over the previous couple of centuries, and has taken the shape of a culture globally. Folks have been exhibiting their inclination in direction of this tradition in numbers that exceed and forecast. Since the boom of publication as want for information was very tremendous in the mid of 20th century. It?s the time when self help publication department prolonged from the mum or dad tree and graduated into a very vivid and fruit bearing portion. Self improvement empowered people with the instruments they require for a self post-mortem for a self modernism of the personality. As is the case that new techniques have to face challenges from the already current traditions. The rise of self assist culture was a victim to the identical rage too.
It was also debated that self help or self improvement books are infecting human considering skills and is making them drift apart from the society in the view of creating a brand new breed. Self help, self improvement, motivational literature, and inspirational books are all synonyms to each other and are a mixed effort to boost the self prognosis, and self evaluating of the limitation that one faces within the numerous spheres of life. Motivational motion also played its very important function of appearing as a bridge between the traditional and the modern. All the self motivational books catering the readers have a combined declare that they have assist individuals, and society as a complete into a really refined, self believing, scientific, properly-engineered, and analytical method in direction of the subject matter there by making the entire human race climb the rostrum of success on the general basic. Self help methodologies usually are not instrumental in itself, the utility and applicability of it might only be magnified only when there are people wi
lling to implement it of their way of life and submit their welcome changes in entrance of the society in order that others can even benefited from. Private development perhaps is a very minute portion of your complete change, there may be military of people joining the up gradation motion and such an amazing drift in the direction of the attaining success.
Source: http://jonathanberent.com/2012/02/self-help-book-on-happiness-tips-2/
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Falling mortgage rates make owning a home more affordable. Mortgage rates are directly tied to monthly mortgage payment so as mortgage rates drop, so does the cost of home-ownership. ?
It?s a money-saving time to buy a home in Woodstock ? or to refinance one. Mortgage rates have never been this low in history.
According to Freddie Mac, last week, the average 30-year fixed rate mortgage fell to 3.87% nationwide for borrowers willing to pay an accompanying 0.8 discount points plus closing costs.?0.8 discount points is a one-time closing cost equal to 0.8 percent of your loan size, or $800 per $100,000 borrowed.
This represents an incredible value as compared to February of last year.?
It was exactly one year ago that mortgage rates begin their long slide lower.?On February 11, 2011, the 30-year fixed rate mortgage reached its peak for the year, reading 5.05% in Freddie Mac?s nationwide survey.?If you are among the many U.S. households that bought or refinanced a home around that time, you could choose to replace your current home loan with a new one and save close to 13% on your monthly mortgage payment.
13 percent saved on your mortgage is a noteworthy statistic.
Look at this 30-year fixed rate mortgage payment comparison over the last 12 months :
Because of falling mortgage rates, a homeowner with a $250,000 30-year fixed rate mortgage would save at least $175 per month just by refinancing into a new loan at today?s mortgage rates.?That?s $2,100 in savings per year.?
Even after accounting for discount points and closing costs, the ?break-even point? on a mortgage like that can come relatively quickly.
We can?t predict mortgage rates so there?s no promise rates will stay like this forever. If you?re planning to buy a home or refinance one, the best way to keep your monthly payments down is to lock your rate while rates are still low.
The market looks ripe for that now.?
Source: http://maxsell.net/mortgage-payments-fall-13-percent/
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A leaky Soyuz decent capsule means that astronauts aboard the International Space Station will have to wait another six weeks before returning home. And private resupply missions are not ready for prime time.
A botched pressure test of a Russian space capsule slated to launch the next crew to the International Space Station has forced NASA and its partners to delay the planned liftoff for more than a month.
Skip to next paragraphThe Russian Soyuz spacecraft launch was originally slated for March 29, but now is targeted for no earlier than May 15, NASA's International Space Station program manager?Mike Suffredini told reporters today (Feb. 2).
The Soyuz's crew capsule, one of three modules that make up the entire Soyuz TMA-04M vehicle, ?has been scrapped after an accident during testing caused it to spring a leak in one of its descent module's rocket thruster fuel tanks. Now Russia's main space contractor, RSC Energia, is readying the next spaceship on the line, though the issue will cause a lengthy delay.
"This particular event is very unfortunate, but you know this is a complicated business and things happen," Suffredini said. "To me this is not indicative of some overarching problem at the Energia corporation. I have every confidence that they'll figure out the cause of this and rectify it for the future."?[Russia's Manned Soyuz Space Capsule Explained (Infographic)]
With the retirement of NASA's space shuttle fleet last year, Russia's three-person Soyuz space capsules are currently the only vehicle available to ferry American astronauts to and from the International Space Station. NASA plans to eventually use private U.S.-built commercial spacecraft to transport crews and cargo to the station, but those new vehicles are still years away from being ready.
Meanwhile, NASA is contemplating another delay ? in this case, of the unmanned SpaceX Dragon capsule's inaugural trip to deliver supplies to the space station. The private spacecraft was due to make its first test launch to the orbiting laboratory on Feb. 7, but Suffredini said the latest target date is March 20, and even that might be a stretch, as the vehicle still requires more testing and some minor fixes.
The faulty Soyuz capsule was slated to carry NASA astronaut Joe Acaba and Russian cosmonauts Gennady Padalka and Sergei Revin up to the space station to begin long-duration stays.
They were due to replace three of the Expedition 30 spaceflyers currently living on the outpost: NASA astronaut Dan Burbank?and Russian cosmonauts Anton Shkaplerov and Anatoly Ivanishin.
However, because of the Soyuz issues, NASA and Russia have decided to extend the current crew's mission to keep the space station running smoothly. Those three were scheduled to return to Earth March 16, but now will come home April 30.
The delay is also likely to cause rippling setbacks in other planned launches and landings later this year.
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February 06, 2012, 10:42 AM ?
Apple makes just under 9% of all cell phones worldwide, but iPhones pull in 75% of profit made by all makers.
Thanks to Horace Dediu of Asymco for this analysis, which tracks the worldwide cell phone market. And worldwide, Apple's iPhone accounts for 8.75 percent of total volume of units sold. Not too impressive for all the hype. But impressive, maybe amazing, is Apple's current share of profits from their handset manufacturing business: they take three of every four dollars, worldwide, of handset profits.
This is up from 39 percent in the second quarter of 2010, so the rise has been meteoric. And since smart phones cost far more than "feature phones," Apple also grabs more revenue than anyone else: 39 percent. Second to Apple, in both profit and revenue, is Samsung, at 16 percent of profit and 25 percent of global revenue. Good numbers, but not nearly Apple numbers.
Remember Apple's unveiling of the OG iPhone? Their goal was 1% of global phone market-share (10M units) by 2008.
r00fus on asymco.com
You're not selling a device. You're selling User Experience and the ecosystem that's built around it. The competition has yet to learn this.
*LTD* on macrumors.com
Apple is actually fighting a two-front war with both the traditional manufacturers and the carriers, who are natural allies (with the carriers dominating the alliance). And Apple is *winning*.
Walter Milliken on asymco.com
Once Apple signs with China Mobile, it's total world domination (75% of profits will look like a joke one or two years from now).
Nicu_Mihalache on fortune.cnn.com
I believe the iPhone will continue to gain market share, raising it from around 8.7% perhaps to as much 30% or more of the entire mobile phone market. The iPhone 5 may stimulate another huge market share surge later this year.
Secular_Investor on asymco.com
At what point are carriers forced to re-negotiate their terms with Apple, or even drop the iPhone altogether? Apple is doing extraordinarily well, but they may also be killing the golden goose.
elko on fortune.cnn.con
But it looks to me as if Apple has transitioned from being a disruptor of the mobile phone business and into a sustainer of the new pocket computer-cum-phone.
Walt French on asymco.com
NOK, back in 2007, was pulling in 55% of the profits.
RadarTheKat on fortune.cnn.com
good luck copying that, samsung
M-O on macrumors.com
Will these numbers have an impact on the Apple-Foxconn production safety issues?
Source: http://www.itworld.com/networking/247476/apple-iphone-cell-market-share-small-profit-share-huge
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A lot of mobile phone home business now had also benefited from this advance technologies. There are mobile phones that have cameras, video and sound players, games, word processors, and even the capability to surf the net.
No doubt mobile phones give us with so numerous positive aspects.
Study shows that folks who consistently use cell phones as a implies of communication could suffer hearing loss in the extended run.
No matter if we like it or not mobile phones emits radiation. Radiation from mobile phones leads to sleep reduction, headaches and confusion. Do not location your phone close to your bed when you sleep. Radiation emitted by mobile phones when sleeping impacts the stages of your sleep.
High-tech cell phones are multi-functional. Mobile phones can without difficulty be cracked. Be very cautious in utilizing your mobile phones.
The Dangers of Cell Phones That No 1 specific Told You About
You see, several of the applications that are claiming that they can do this for you, are scams, not operating or fake.So, in order to stay clear of receiving these scams, it really is highly recommended that you only get a cell telephone spy plan which has received a awesome number of awesome feedback, and which has obtained a high reputation.What Cell Telephone Spy Computer software To Use When You Want To Spy On Any PersonA outstanding plan is referred to as Spybubble, and it honestly is really suggested that you download this cell telephone spy software program package. (Spy on received and sent messages.)
Source: http://www.nut-container.org/cell-telephone-spy-how-to-very-easily-spy-on-any-cell-phone.html
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![[ Back to EurekAlert! ]](http://www.eurekalert.org/images/back2e.gif){kind=small}
Public release date: 6-Feb-2012
Share ] Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
EDITOR'S PICK: The heart can make 'bad' fat burn calories
Brown adipose tissue (often known as brown fat) is a specialized tissue that burns calories to generate body heat in rodents and newborn humans. Recently, adult humans have also been found to possess brown fat. This piqued the interest of researchers seeking to combat the obesity epidemic, the thought being that increasing the amount of brown fat a person has will make them lose weight. A team of researchers led by Sheila Collins, at the Sanford-Burnham Medical Research Institute, Orlando, has now determined that hormones produced by the heart known as cardiac natriuretic peptides can cause regular fat cells (white adipocytes) from mice and humans to take on characteristics of brown fat cells in vitro. Moreover, infusing one cardiac natriuretic peptide into mice caused regular white fat to upregulate markers of brown fat and increase energy usage. Collins and colleagues hope that with further mechanistic studies it might be possible to exploit these findings clinically to help combat the obesity epidemic.
In an accompanying commentary, Andrew Whittle and Antonio Vidal-Puig, at the University of Cambridge, United Kingdom, highlight the importance of the data generated by Collins and colleagues and discuss the clinical implications of the results.
TITLE: Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
AUTHOR CONTACT:
Sheila Collins
Sanford-Burnham Medical Research Institute, Orlando, Florida, USA.
Phone: 407-745-2134; Fax: 407-745-2032; E-mail: scollins@sanfordburnham.org.
View this article at: http://www.jci.org/articles/view/59701?key=71c8f4e7f1ce5a9bf63d
ACCOMPANYING COMMENTARY TITLE: NPs heart hormones that regulate brown fat?
AUTHOR CONTACT:
Antonio Vidal-Puig
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic
Science, Cambridge, United Kingdom.
Phone: 44-1223-762790; Fax: 44-1223-330598; E-mail: ajv22@cam.ac.uk.
View this article at: http://www.jci.org/articles/view/62595?key=c907b50be9398cbe1b30
IMMUNOLOGY: How a stomach-colonizing bacterium protects against asthma
The bacterium Helicobacter pylori can be found colonizing the stomach lining of almost half the world's population. Although persistent infection with Helicobacter pylori increases an individual's risk of developing stomach cancer, it also decreases their risk of developing asthma. A team of researchers led by Anne Mller, at the University of Zrich, Switzerland, has now identified a cellular mechanism by which persistent infection with Helicobacter pylori protects mice from developing allergic asthma. Specifically, they found that Helicobacter pylori modulated immune cells known as dendritic cells such that they did not activate an aggressive immune response but instead activated what is known as a tolerogenic immune response. Although this tolerogenic immune response enabled Helicobacter pylori to persist, it also prevented the onset of unwanted immune responses to allergens (that is, it protected against allergic asthma).
As noted by Kouji Matsushima and Shigenori Nagai, in an accompanying commentary, these data provide new mechanistic insight into the intriguing link between the recent sharp rise in the industrialized world in the number of people with asthma and the simultaneous decrease in exposure to microbes, including Helicobacter pylori.
TITLE: DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylorispecific immune tolerance, and asthma protection
AUTHOR CONTACT:
Anne Mller
Institute of Molecular Cancer Research, University of Zrich, Zrich, Switzerland.
Phone 41-44-635-3474; Fax: 41-44-635-3484; E-mail: mueller@imcr.uzh.ch.
View this article at: http://www.jci.org/articles/view/61029?key=43b6bf2cd6676065e46e
ACCOMPANYING COMMENTARY TITLE: Unraveling the mystery of the hygiene hypothesis through Helicobacter pylori infection
AUTHOR CONTACT:
Kouji Matsushima
Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Phone: 81-3-5841-3431; Fax: 81-3-5841-3393; E-mail: koujim@m.u-tokyo.ac.jp.
View this article at: http://www.jci.org/articles/view/61466?key=ab4d0ae3b04251fa1b4f
ONCOLOGY: A sticky problem for stomach cancer
Gastric cancer cancer that arises in the stomach is a leading cause of cancer-related death. A team of researchers led by Jun Nakayama, at Shinshu University Graduate School of Medicine, Japan, has now found that gel-forming mucin secreted by glands in the stomach lining suppresses tumor-promoting inflammation in mice.
Mucin secreted by glands in the stomach lining is characterized by the presence of specific molecules at its ends. These molecules are known as alpha-1,4-linked N-acetylglucosamine residues (alpha-GlcNAc). Nakayama and colleagues found that mice lacking the ability to add alpha-GlcNAc to the ends of mucin secreted by glands in the stomach lining developed stomach cancer. Moreover, expression of alpha-GlcNAc was decreased in the majority of human gastric cancer samples examined. As their previous studies have suggested that alpha-GlcNAccontaining mucin inhibits infection with the bacterium Helicobacter pylori, which is a major risk factor for developing gastric cancer, Nakayama and colleagues suggest that alpha-GlcNAccontaining mucin prevents gastric cancer in two ways: by inhibiting Helicobacter pylori infection and by suppressing tumor-promoting inflammation.
TITLE: Essential role of gastric gland mucin in preventing gastric cancer in mice
AUTHOR CONTACT:
Jun Nakayama
Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Phone: 81-263-37-3394; Fax: 81-263-37-2581; E-mail: jnaka@shinshu-u.ac.jp.
View this article at: http://www.jci.org/articles/view/59087?key=262b13135d1ff1bd59fd
ONCOLOGY: New controller of cancer cell multiplication identified
One of the hallmarks of cancer is the ability of cancer cells to proliferate in an uncontrolled manner. The proteins c-Jun and c-Myc have a key role in promoting cell proliferation, and many human cancers are characterized by aberrant expression of these proteins. Understanding how expression of c-Jun and c-Myc is controlled could provide new insight into the mechanisms underlying tumor formation as well as provide new candidate therapeutic targets. In this context, Kiyotsugu Yoshida and colleagues, at Tokyo Medical and Dental University, Japan, have determined that the protein DYRK2 has a key role in regulating levels of c-Jun and c-Myc in human cells knocking down levels of DYRK2 in human cancer cells increased cell proliferation in vitro and upon transplantation into mice. Moreover, expression of DYRK2 was decreased in tissue samples of many different types of cancer, including breast, colon, prostate, and kidney cancers. Yoshida and colleagues therefore suggest that restoring DYRK2 expression could provide a new approach to treating many different forms of cancer.
TITLE: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells
AUTHOR CONTACT:
Kiyotsugu Yoshida
Tokyo Medical and Dental University, Tokyo, Japan.
Phone: 81-3-5803-5826; Fax: 81-3-5803.0242; E-mail: yos.mgen@mri.tmd.ac.jp.
View this article at: http://www.jci.org/articles/view/60818?key=3ce39f511160966595a6
ONCOLOGY: Promoting instability in cancer cells
Many cancer cells are characterized by gain or loss of whole chromosomes and/or major structural changes to chromosomes. These chromosomal changes, which are said to indicate chromosomal instability, often drive tumor formation and/or progression by causing overexpression of tumor-promoting proteins or generation of tumor-promoting fusion proteins. Understanding the mechanisms underlying chromosomal instability should provide new insight into the mechanisms underlying tumor formation/progression as well as provide new candidate therapeutic targets. In this context, a team of researchers led by Richard Pestell, at Thomas Jefferson University, Philadelphia, has now determined that the protein cyclin D1 induces chromosomal instability and increased breast tumor prevalence in mice. Moreover, analysis of human breast tumor samples indicated that cyclin D1 expression correlated with chromosomal instability in the luminal B subtype of breast cancer. Additional experiments indicated that cyclin D1 mediated its effects by increasing expression of numerous genes related to chromosomal instability. Further analysis of this mechanism could provide new targets for anticancer therapies.
TITLE: ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
AUTHOR CONTACT:
Richard G. Pestell
Thomas Jefferson University and Hospital, Kimmel Cancer Center, Philadelphia,
Pennsylvania, USA.
Phone: 215-503-5692; Fax: 215-503-9334; E-mail: Richard.pestell@jefferson.edu.
View this article at: http://www.jci.org/articles/view/60256?key=bf3b3d5f3177c46ce3f7
NEUROLOGICAL DISEASE: Site-specific nerve damage explained
Guillain-Barr syndromes (GBSs) are medical conditions in which a person's immune system attacks their peripheral nervous system the nerves outside the brain and spinal cord causing varying degrees of weakness, tingling sensations, and/or pain in the legs, arms, and upper body. In individuals with the acute motor axonal neuropathy (AMAN) form of GBS, nerve damage is associated with the presence of specific immune factors: antibodies that recognize molecules known as gangliosides (anti-ganglioside antibodies [AGAbs]). A team of researchers led by Hugh Willison, at the University of Glasgow, United Kingdom, has now clarified an important open question regarding which parts of peripheral nerves are damaged by AGAbs using a variety of cell- and tissue-based model systems. These data provide new insight into ways in which nerve damage is modulated at different sites.
TITLE: Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy
AUTHOR CONTACT:
Hugh J. Willison
Institute of Infection, Immunity and Inflammation, University of Glasgow,
Glasgow, United Kingdom.
Phone: 44-141-330-8384; Fax: 44-141-201-2993; E-mail: Hugh.Willison@glasgow.ac.uk.
View this article at: http://www.jci.org/articles/view/59110?key=c3564f6a73e1f8b5491d
###
[ | E-mail | Share ] ?
AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.
Public release date: 6-Feb-2012 Share ] Contact: Karen Honey
press_releases@the-jci.org
734-546-5242
Journal of Clinical Investigation
EDITOR'S PICK: The heart can make 'bad' fat burn calories
Brown adipose tissue (often known as brown fat) is a specialized tissue that burns calories to generate body heat in rodents and newborn humans. Recently, adult humans have also been found to possess brown fat. This piqued the interest of researchers seeking to combat the obesity epidemic, the thought being that increasing the amount of brown fat a person has will make them lose weight. A team of researchers led by Sheila Collins, at the Sanford-Burnham Medical Research Institute, Orlando, has now determined that hormones produced by the heart known as cardiac natriuretic peptides can cause regular fat cells (white adipocytes) from mice and humans to take on characteristics of brown fat cells in vitro. Moreover, infusing one cardiac natriuretic peptide into mice caused regular white fat to upregulate markers of brown fat and increase energy usage. Collins and colleagues hope that with further mechanistic studies it might be possible to exploit these findings clinically to help combat the obesity epidemic.
In an accompanying commentary, Andrew Whittle and Antonio Vidal-Puig, at the University of Cambridge, United Kingdom, highlight the importance of the data generated by Collins and colleagues and discuss the clinical implications of the results.
TITLE: Cardiac natriuretic peptides act via p38 MAPK to induce the brown fat thermogenic program in mouse and human adipocytes
AUTHOR CONTACT:
Sheila Collins
Sanford-Burnham Medical Research Institute, Orlando, Florida, USA.
Phone: 407-745-2134; Fax: 407-745-2032; E-mail: scollins@sanfordburnham.org.
View this article at: http://www.jci.org/articles/view/59701?key=71c8f4e7f1ce5a9bf63d
ACCOMPANYING COMMENTARY TITLE: NPs heart hormones that regulate brown fat?
AUTHOR CONTACT:
Antonio Vidal-Puig
University of Cambridge Metabolic Research Laboratories, Institute of Metabolic
Science, Cambridge, United Kingdom.
Phone: 44-1223-762790; Fax: 44-1223-330598; E-mail: ajv22@cam.ac.uk.
View this article at: http://www.jci.org/articles/view/62595?key=c907b50be9398cbe1b30
IMMUNOLOGY: How a stomach-colonizing bacterium protects against asthma
The bacterium Helicobacter pylori can be found colonizing the stomach lining of almost half the world's population. Although persistent infection with Helicobacter pylori increases an individual's risk of developing stomach cancer, it also decreases their risk of developing asthma. A team of researchers led by Anne Mller, at the University of Zrich, Switzerland, has now identified a cellular mechanism by which persistent infection with Helicobacter pylori protects mice from developing allergic asthma. Specifically, they found that Helicobacter pylori modulated immune cells known as dendritic cells such that they did not activate an aggressive immune response but instead activated what is known as a tolerogenic immune response. Although this tolerogenic immune response enabled Helicobacter pylori to persist, it also prevented the onset of unwanted immune responses to allergens (that is, it protected against allergic asthma).
As noted by Kouji Matsushima and Shigenori Nagai, in an accompanying commentary, these data provide new mechanistic insight into the intriguing link between the recent sharp rise in the industrialized world in the number of people with asthma and the simultaneous decrease in exposure to microbes, including Helicobacter pylori.
TITLE: DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylorispecific immune tolerance, and asthma protection
AUTHOR CONTACT:
Anne Mller
Institute of Molecular Cancer Research, University of Zrich, Zrich, Switzerland.
Phone 41-44-635-3474; Fax: 41-44-635-3484; E-mail: mueller@imcr.uzh.ch.
View this article at: http://www.jci.org/articles/view/61029?key=43b6bf2cd6676065e46e
ACCOMPANYING COMMENTARY TITLE: Unraveling the mystery of the hygiene hypothesis through Helicobacter pylori infection
AUTHOR CONTACT:
Kouji Matsushima
Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Phone: 81-3-5841-3431; Fax: 81-3-5841-3393; E-mail: koujim@m.u-tokyo.ac.jp.
View this article at: http://www.jci.org/articles/view/61466?key=ab4d0ae3b04251fa1b4f
ONCOLOGY: A sticky problem for stomach cancer
Gastric cancer cancer that arises in the stomach is a leading cause of cancer-related death. A team of researchers led by Jun Nakayama, at Shinshu University Graduate School of Medicine, Japan, has now found that gel-forming mucin secreted by glands in the stomach lining suppresses tumor-promoting inflammation in mice.
Mucin secreted by glands in the stomach lining is characterized by the presence of specific molecules at its ends. These molecules are known as alpha-1,4-linked N-acetylglucosamine residues (alpha-GlcNAc). Nakayama and colleagues found that mice lacking the ability to add alpha-GlcNAc to the ends of mucin secreted by glands in the stomach lining developed stomach cancer. Moreover, expression of alpha-GlcNAc was decreased in the majority of human gastric cancer samples examined. As their previous studies have suggested that alpha-GlcNAccontaining mucin inhibits infection with the bacterium Helicobacter pylori, which is a major risk factor for developing gastric cancer, Nakayama and colleagues suggest that alpha-GlcNAccontaining mucin prevents gastric cancer in two ways: by inhibiting Helicobacter pylori infection and by suppressing tumor-promoting inflammation.
TITLE: Essential role of gastric gland mucin in preventing gastric cancer in mice
AUTHOR CONTACT:
Jun Nakayama
Shinshu University Graduate School of Medicine, Matsumoto, Japan.
Phone: 81-263-37-3394; Fax: 81-263-37-2581; E-mail: jnaka@shinshu-u.ac.jp.
View this article at: http://www.jci.org/articles/view/59087?key=262b13135d1ff1bd59fd
ONCOLOGY: New controller of cancer cell multiplication identified
One of the hallmarks of cancer is the ability of cancer cells to proliferate in an uncontrolled manner. The proteins c-Jun and c-Myc have a key role in promoting cell proliferation, and many human cancers are characterized by aberrant expression of these proteins. Understanding how expression of c-Jun and c-Myc is controlled could provide new insight into the mechanisms underlying tumor formation as well as provide new candidate therapeutic targets. In this context, Kiyotsugu Yoshida and colleagues, at Tokyo Medical and Dental University, Japan, have determined that the protein DYRK2 has a key role in regulating levels of c-Jun and c-Myc in human cells knocking down levels of DYRK2 in human cancer cells increased cell proliferation in vitro and upon transplantation into mice. Moreover, expression of DYRK2 was decreased in tissue samples of many different types of cancer, including breast, colon, prostate, and kidney cancers. Yoshida and colleagues therefore suggest that restoring DYRK2 expression could provide a new approach to treating many different forms of cancer.
TITLE: DYRK2 priming phosphorylation of c-Jun and c-Myc modulates cell cycle progression in human cancer cells
AUTHOR CONTACT:
Kiyotsugu Yoshida
Tokyo Medical and Dental University, Tokyo, Japan.
Phone: 81-3-5803-5826; Fax: 81-3-5803.0242; E-mail: yos.mgen@mri.tmd.ac.jp.
View this article at: http://www.jci.org/articles/view/60818?key=3ce39f511160966595a6
ONCOLOGY: Promoting instability in cancer cells
Many cancer cells are characterized by gain or loss of whole chromosomes and/or major structural changes to chromosomes. These chromosomal changes, which are said to indicate chromosomal instability, often drive tumor formation and/or progression by causing overexpression of tumor-promoting proteins or generation of tumor-promoting fusion proteins. Understanding the mechanisms underlying chromosomal instability should provide new insight into the mechanisms underlying tumor formation/progression as well as provide new candidate therapeutic targets. In this context, a team of researchers led by Richard Pestell, at Thomas Jefferson University, Philadelphia, has now determined that the protein cyclin D1 induces chromosomal instability and increased breast tumor prevalence in mice. Moreover, analysis of human breast tumor samples indicated that cyclin D1 expression correlated with chromosomal instability in the luminal B subtype of breast cancer. Additional experiments indicated that cyclin D1 mediated its effects by increasing expression of numerous genes related to chromosomal instability. Further analysis of this mechanism could provide new targets for anticancer therapies.
TITLE: ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
AUTHOR CONTACT:
Richard G. Pestell
Thomas Jefferson University and Hospital, Kimmel Cancer Center, Philadelphia,
Pennsylvania, USA.
Phone: 215-503-5692; Fax: 215-503-9334; E-mail: Richard.pestell@jefferson.edu.
View this article at: http://www.jci.org/articles/view/60256?key=bf3b3d5f3177c46ce3f7
NEUROLOGICAL DISEASE: Site-specific nerve damage explained
Guillain-Barr syndromes (GBSs) are medical conditions in which a person's immune system attacks their peripheral nervous system the nerves outside the brain and spinal cord causing varying degrees of weakness, tingling sensations, and/or pain in the legs, arms, and upper body. In individuals with the acute motor axonal neuropathy (AMAN) form of GBS, nerve damage is associated with the presence of specific immune factors: antibodies that recognize molecules known as gangliosides (anti-ganglioside antibodies [AGAbs]). A team of researchers led by Hugh Willison, at the University of Glasgow, United Kingdom, has now clarified an important open question regarding which parts of peripheral nerves are damaged by AGAbs using a variety of cell- and tissue-based model systems. These data provide new insight into ways in which nerve damage is modulated at different sites.
TITLE: Anti-ganglioside antibody internalization attenuates motor nerve terminal injury in a mouse model of acute motor axonal neuropathy
AUTHOR CONTACT:
Hugh J. Willison
Institute of Infection, Immunity and Inflammation, University of Glasgow,
Glasgow, United Kingdom.
Phone: 44-141-330-8384; Fax: 44-141-201-2993; E-mail: Hugh.Willison@glasgow.ac.uk.
View this article at: http://www.jci.org/articles/view/59110?key=c3564f6a73e1f8b5491d
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Using the increased access to fast food and processed food much of today's generation have cultivated up on microwavable meals and ready-made foods. This has ended in poor eating habits and has led to a marked increase and worry over the amount of adults and children who are suffering from obesity. Millions of bucks are spent through people on diet products and regimes just trying to lose weight. The choice of diet and exercise products on the market today is immense along with there aren't many that many haven't yet tested leading to the query of why so most of us are still gaining weight. In many other nations the principle diet differs significantly compared to that of Americans and several don't have exposure to the number of processed food even as do. They also drink green tea herb regularly. It seems that various other people have had the knowledge for years that there is a connection between teas and weight loss and general a sound body.
Green tea hails from the plant Camellia Sinensis, the same plant that is also used to create black tea. Research has shown effectiveness in encouraging weight reduction. It may not be considered a quick fix that will make people slim in several, and the person must still maintain balanced and healthy diet as well as carry on and excercise. {bearing all this/keeping this all in mind, there is a connection between green tea and weight loss and now giant pharmaceutical companies such as Boots plc in the UK are putting Green Tea extract in to their latest dietary products.
Listed here are a few of the fundamental benefits of ingesting green towards weight loss:
-????????????? Green tea will increase the body's metabolism over a longer period of time in the same manner that exercise increases the physique's metabolism.
-????????????? Green tea uses fats for vitality over the day making it a popular approach for other folks like body builders to burn away the surplus fat.
-????????????? It slows the release of carbohydrates down within the physique which acts as a dam by not letting giant amounts of blood glucose to spike within the body.
-????????????? Green Tea with catechins helps to prevent obesity by slowing the glucose in fat cells.
The Hand in Hand Advantages of Green Tea and Weight Loss
People gain weight by consuming foods with fats and extra sugars. There are further research needed on the contributing components of green tea helping in the direction of weight loss nevertheless, there is certainly enough constructive info between the studies to provide a strong indication that green tea is a beneficial contributor in the direction of weight loss and largely green tea has now been shown to help the body lose weight. Whereas there is no definitive amount wanted to induce its weight loss and the fat burning results, an excellent recommendation for the amount needed to elicit weight loss and the entire different reported benefits can be 2 3 6- servings/day, alternatively one can try dietary supplements and green tea fat burners in a capsule type in the event that they actually can't drink too much tea through the day.
Green tea tastes good and it is good for the physique and there aren't many foods that taste good and are good! It's too unhealthy? the rest of our diets seem to be good however they are high in fats! Green tea and weight loss can go hand in had and green tea does have even more advantages than just aiding weight loss. It might assist one to live longer and stay healthier.Source: http://greenweightloss-tea.blogspot.com/2012/02/drinking-green-tea-and-weight-loss.html
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It is important to work on your personal development. Personal development includes virtually every aspect of your life, including what you eat and how you manage your finances. You need to work to better yourself. There is always something you can improve on, keep this in mind as you strive to become a better person in life. You are sure to have a much happier and healthier life if you find a way to develop and maintain good habits every day.
To live life fully, you must be willing to take some risks. Many people get stuck in a zone that is comfortable so they do not risk failure or rejection, but the true risk is the loss of opportunities for personal growth. Furthermore, taking reasonable risks shows that you are brave. This boost to your self confidence will carry you far!
Whereas trying to fix your problems yourself is always a great idea, sometimes you might have to seek out professional help. Though self-help books and online resources are great, they typically will not offer as much as a one-on-one therapy session can. Sometimes, simply talking through your problems can help you conquer them. A book can not talk to you like a therapist can.
If you experience trouble meeting the personal development goals you set for yourself, do not be afraid to stop and make a frank assessment of the problem. Research your ideas online to find others who have set similar goals, then compare yours with those of others. It is possible that you may be setting unrealistic expectations, missing an important element, or not devoting enough time or resources to your efforts.
It is important to treat your body well and listen to its signals. If you feel thirsty, hungry, etc., you need to correct that issue right away. Once you do this, your body will be better able to aid you for the long term. Ignoring those needs may cause your body to ignore you.
Building a better you starts with building leadership tendencies. The best definition for leadership is ?influence?. Analyze your leadership progress. Which past events have had major, formative effects on your life? How have you changed because of those events? What are your qualities that make you shine in a team environment? Ask yourself these questions in order to see how you will be as a member of a team.
If you don?t take care of yourself, you won?t be able to take care of others. Take time for rest and relaxation, whether your health is good or poor.
Learning to take controlled risks could bring you happiness. A lot of people find themselves stuck in their comfort zone, because they do not dare take risks and fear rejection. Taking risks shows courage, which is a component that can help you on the path of happiness.
By now, you surely have tons of great new ideas for becoming a stronger person. Hopefully, this knowledge has left you feeling inspired and ready to take action. Never stop seeking ways to develop yourself as a person. Use that knowledge to become the person you seek to be.
Many thanks for reviewing my article. In case you enjoy the writings, please see my current web sites related to online learning, more specifically about what to do to receive an online doctorate organizational leadership. Please leave your thoughts should you like my online doctorate accredited info.
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Vitamin complement or nutritional supplements are really substantial for us simply because if we don?t consumption lots vitamins essential for our bodies, the vitamin complement will substitute for the shortage with the number of vitamins inside our technique.
Eating plan nutritional nutritional supplements, or dietary nutritional supplements, are formulated to deliver vitamins and minerals these as vitamins, minerals, amino acids, and fatty acids to folks who?re not consuming the enough each day prerequisites that represent a well-balanced food plan. Technically, dietary nutritional supplements also include things like herbal nutritional supplements, which claim to assist inside the prevention or treatment method of selected disorders and illnesses.
Nevertheless, a helpful food plan supported on foods with large focus of vitamins is often a more recommended remedy than nutritional supplements. But each time a food plan just isn?t lots, propane fire pits might be the answer.
Nutritious articles statements for dietetic complement vitamin explain the stage of extraordinary form of vitamin or vitamins in that complement. For example, accordant to several wellness organizations, a dietetic complement vitamin with at the least twelve milligrams per portion of vitamin Do could possibly have the subsequent declaration on its label: ?Excellent resource of vitamin Do.?
There are numerous best vitamin d supplement that could interfere with many others when your body absorbs them, which means you need to constantly ensure what you are taking is appropriate to choose with other varieties of vitamin nutritional supplements. Beneath, is a list with the most common vitamins and how it is best to go about taking them
Every time that you are selected that you?re not obtaining ample vitamins to supply what your whole body demands, you then need to purchase a vitamin complement.Coming up with a vitamin complement that can assist you to achieve finest wellness might be much more smoother than you consider. There are many vitamin nutritional supplements from which to choose. As a way to occur up while using right vitamin solution, you will need to look over labels and examine goods.
Always try to remember which the 205/55 16 Administration Board doesn?t regulate the produce and sale of vitamin and nutritional nutritional supplements. As a result, it truly is critical to try to look for a nutritional complement producer that strictly complies with GMP requirements. GMP-compliance assures you that an item is examined for cleanliness and it is free of contaminants and prescribed drugs. Furthermore, it assures you that an item consists of the correct number of components and dosage, based on the Suggested Dietary Allowances and as indicated inside the label.
Vitamin nutritional supplements can be found within a quantity of different varieties, which include capsules, tabs, liquids, and even chewable tabs. Also, there is a fantastic wide variety inside the manufacturers as well as the real articles with the vitamin nutritional supplements.Do some research and uncover out what these vitamin nutritional supplements incorporate. Spend consideration to doses, components, security safeguards, and other critical info.Get the correct complement available for you, and when in doubt, refer a doctor or your wellness expert ahead of obtaining any vitamin nutritional supplements.
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Muscle building champions are not cut in the same cloth as the majority of people. Body building dependence seems to affect men and women body builders equally, despite previous claims that it?s predominantly a male problem. Muscle building is the process of developing muscle through the mixture of weight lifting, increased calorie intake, and rest. Muscle building nutritional supplements are easily obtainable in every health food store and most gyms. Body building not just can help you physically but mentally as well since it builds self-confidence, enables you to more disciplined helping you achieve your goals in life.
Protein
Whey protein and soy protein are protein supplements effective for bodybuilding in men and women. Additionally, during the off-season, adequate protein must be open to provide proteins for protein synthesis. Furthermore, throughout the pre-contest phase, protein intake must be adequate to maintain muscle tissue. A relatively high protein intake (approximately 30% of one?s intake) reduces lean mass loss relative to a lesser protein intake (approximately 15% of energy intake) during energy restriction. The higher protein intake will even give a relatively large thermic effect that could aid in reducing body fat. Consumption of protein / amino acids and carbohydrate immediately before and after workout sessions may augment protein synthesis, muscle glycogen resynthesis and lower protein degradation. Most body-builders believe they must consume large amounts of protein daily to get results. Many body builders take up to 45% of their calories as protein, believing this leads to large muscle gain.
Builder
Others believe bodybuilder discipline is the answer. To begin with, bodybuilders realize that a strong mind and a strong body go together. Despite all these wonderful preventative measures, however, sometimes even the bodybuilder can go astray. The champion bodybuilders that you read about and find out within the magazines are experts in modeling. Many professional Body Builders realize that their imagery and mental techniques take into account a big part of the success. Only 20 minutes each day, and you?ll discover how the successful bodybuilders make such impressive gains in such a short time. Somebody that partcipates in this activity is called a bodybuilder. As a sport (competitive bodybuilding) bodybuilders display their physiques to a panel of judges, who assign points based on their aesthetic appearance. Body builders use resistance weight training to improve muscle size. ?However,? they explain, ?many differences exist in the motivations and psychological characteristics of bodybuilders compared with other exercising populations.
Body building is really a sport whereby competitive bodybuilders display their muscular bodies in front of a panel of judges who assign points to determine the rankings and prize awards. Muscle building is tough enough without feeling frustrated and defeated when you look in the mirror. Body building benches are fairly inexpensive new, and when you frequent rummage sales, you?ll likely stumble upon a cheap used bench once in awhile. Muscle building can be achieved on a budget, no doubt about this.
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The unemployment rate has dropped from 8.5% to 8.3% after the January unemployment report showed US employers added 243,000 jobs for the month. A CNBC panel discusses the data.
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SAVANNAH, Ga. ? Lee Adler II was never content with saving Savannah's historic homes and buildings one at a time. In 1959, he found a way to spare entire city blocks and neighborhoods from the wrecking ball that changed the way preservation groups did business ? not just in Georgia, but across the nation.
Adler died Sunday at age 88, said Matt Weeks of Fox & Weeks Funeral Directors. A cause of death was not immediately available.
As the president of the Historic Savannah Foundation, which Adler led until the mid-1960s, he took an entrepreneurial approach to saving Savannah's architectural treasures by essentially persuading local preservationists to get into the real estate business. The group would buy sagging old properties facing demolition and sell them to buyers who promised to restore them. The tactic worked so well in Savannah that groups across the U.S. began following Adler's lead.
"There's not a preservation group in this country that doesn't owe some debt of gratitude to the work of Lee Adler," said David J. Brown, chief preservation officer at the National Trust for Historic Preservation in Washington.
Adler, usually working in tandem with his wife, Emma, became an evangelist for the methods he'd used in Savannah. He would tout his hometown's success at preservation conferences and conventions and even to individual groups across the nation. He also co-wrote a handbook on the subject in 1974.
"Lee's the kind of person who was a lot more respected outside of Savannah than he was in Savannah, because inside the city a lot of people took preservation for granted," said Mark McDonald, a longtime friend of Adler and the president of the Atlanta-based Georgia Trust for Historic Preservation. "He gave people the idea they could do this in their hometown just like they'd done it in Savannah."
The influence was noted in "Midnight in the Garden of Good and Evil," John Berendt's best-selling book about a murder in Savannah. Berendt wrote that because of Adler's work in historic preservation, "Lee Adler was probably the best-known Savannahian outside Savannah" by the 1980s.
Born into a wealthy Savannah family that owned a local department store, Adler's passion for protecting the 18th and 19th century homes of Georgia's oldest city was passed on by his mother.
Elinor Grunsfeld Adler was among the seven women who launched the foundation that her son would later lead. The women started the group in 1954 to show their outrage after the downtown City Market, where farmers sold their crops, was razed to make way for a parking garage.
The preservation group saved other homes and buildings, typically turning them into museums, during a time when the suburban flight that followed World War II left Savannah's oldest neighborhoods decaying and abandoned. The fledgling foundation's methods would change dramatically under Lee Adler's leadership years later.
In 1959, he learned a wrecking company had a permit to demolish four century-old townhouses in downtown Savannah with the intention of selling the bricks for a profit. Adler quickly struck a deal to buy the entire row for $54,000 and got the Historic Savannah Foundation's members to agree to share the cost ? $180 for each of its 300 members. The homes were later sold to new owners.
Daniel Carey, the foundation's current president and a longtime friend of Adler, said the revolving-fund technique Adler popularized is credited with saving more than 350 homes and buildings in Savannah, where the 2.2-square-mile downtown area forms America's largest National Historic Landmark District.
"Historically there were efforts to save one building at a time, call it a success and kind of take a victory lap and be finished," Carey said. "Lee and others said this is really just the beginning, not the end. So they said we can save a block at a time and neighborhood at a time ? and eventually a city at a time."
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Nick & Aaron Carter’s Sister Leslie Carter Dead At 25! (Photos/Videos)
Nick and Aaron Carter‘s sister Leslie has died at the young age of 25. Leslie Carter passed away in New York yesterday and the family [...]
Nick & Aaron Carter’s Sister Leslie Carter Dead At 25! (Photos/Videos) Stupid Celebrities Gossip Stupid Celebrities Gossip News
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